About ¼ or a fourth of the way, you can stop at Fort Winfield Scott, CA. This is about 15 minutes northwest of San Francisco.
About ⅓ or a third of the way, you can stop at Tiburon, CA. This is about half an hour north of San Francisco.
If you drive straight through without stopping at all, the total distance is 24 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 59 minutes.
