If you're looking for a meeting place or a good stop around ½ or halfway between San Francisco and Los Gatos, you can try Redwood City, CA, which is about half an hour southeast of San Francisco, or about half an hour northwest of Los Gatos.
About ¼ or a fourth of the way, you can stop at San Bruno, CA. This is about 14 minutes south of San Francisco.
About ⅓ or a third of the way, you can stop at San Mateo, CA. This is about 16 minutes south of San Francisco.
About ⅔ or two thirds of the way, you can stop at Sunnyvale, CA. This is about half an hour southeast of San Francisco, or about 16 minutes northwest of Los Gatos.
If you drive straight through without stopping at all, the total distance is 52 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 52 minutes.