If you're looking for a meeting place or a good stop around ½ or halfway between Newfoundland and Labrador and Ontario, you can try Edmundston, Canada, which is about 20½ hours west of Newfoundland and Labrador, or a little over 19 hours east of Ontario.
Other possible places to stop near the midpoint include Houlton, Caribou, Grand Falls, Cabano, and Riviere-du-loup.
About ¼ or a fourth of the way, you can stop at Sydney, Canada. This is about 9 hours southwest of Newfoundland and Labrador.
About ⅓ or a third of the way, you can stop at Truro, Canada. This is about 13 hours southwest of Newfoundland and Labrador.
About ⅔ or two thirds of the way, you can stop at Montreal, Canada. This is a little over 27 hours west of Newfoundland and Labrador, or about 12½ hours east of Ontario.
About ¾ or three fourths of the way, you can stop at Mont-Tremblant, Canada. This is about 28½ hours west of Newfoundland and Labrador, or a little over 11 hours east of Ontario.
If you drive straight through without stopping at all, the total distance is 3174 km. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 39 hours, 42 minutes.