If you're looking for a meeting place or a good stop around ½ or halfway between New York and Lowell, you can try Hartford, CT, which is almost 2 hours northeast of New York, or about 2 hours southwest of Lowell.
About ¼ or a fourth of the way, you can stop at Bridgeport, CT. This is almost an hour northeast of New York.
About ⅓ or a third of the way, you can stop at New Haven, CT. This is a little over 1 hour northeast of New York.
About ⅔ or two thirds of the way, you can stop at Southbridge, MA. This is about 2½ hours northeast of New York, or a little over 1 hour southwest of Lowell.
About ¾ or three fourths of the way, you can stop at Worcester, MA. This is almost 3 hours northeast of New York, or almost an hour southwest of Lowell.
If you drive straight through without stopping at all, the total distance is 220 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 3 hours, 41 minutes.