About ⅔ or two thirds of the way, you can stop at Coral Springs, FL. This is about 1½ hours east of Naples, FL, or almost an hour southwest of West Palm Beach.
About ¾ or three fourths of the way, you can stop at Pompano Beach, FL. This is almost 2 hours east of Naples, FL, or about half an hour south of West Palm Beach.
If you drive straight through without stopping at all, the total distance is 149 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 2 hours, 18 minutes.