If you're looking for a meeting place or a good stop around ½ or halfway between Lovettsville and Roanoke, you can try Staunton, VA, which is about 2 hours southwest of Lovettsville, or about 1½ hours northeast of Roanoke.
About ¼ or a fourth of the way, you can stop at Front Royal, VA. This is almost an hour southwest of Lovettsville.
About ⅓ or a third of the way, you can stop at Strasburg Junction, VA. This is about 1 hour southwest of Lovettsville.
About ⅔ or two thirds of the way, you can stop at Davis, VA. This is a little over 2 hours southwest of Lovettsville, or about 1 hour northeast of Roanoke.
About ¾ or three fourths of the way, you can stop at Spottswood, VA. This is about 2½ hours southwest of Lovettsville, or almost an hour northeast of Roanoke.
If you drive straight through without stopping at all, the total distance is 214 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 3 hours, 23 minutes.