If you're looking for a meeting place or a good stop around ½ or halfway between Louisville and Ekron, you can try Corydon, IN, which is about half an hour west of Louisville, or about half an hour north of Ekron.
About ¼ or a fourth of the way, you can stop at Edwardsville, IN. This is about 14 minutes west of Louisville.
About ¾ or three fourths of the way, you can stop at Glidas, IN. This is almost an hour southwest of Louisville, or about 14 minutes north of Ekron.
If you drive straight through without stopping at all, the total distance is 47 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 55 minutes.