About ¼ or a fourth of the way, you can stop at Duncan, IN. This is about 12 minutes west of Louisville.
About ¾ or three fourths of the way, you can stop at Central, IN. This is about half an hour southwest of Louisville, or about 12 minutes north of Brandenburg, KY.
If you drive straight through without stopping at all, the total distance is 43 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 49 minutes.