If you're looking for a meeting place or a good stop around ½ or halfway between Fort Wayne and Syracuse, IN, you can try Merriam, IN, which is about half an hour northwest of Fort Wayne, or about half an hour southeast of Syracuse, IN.
About ⅓ or a third of the way, you can stop at Churubusco, IN. This is about 18 minutes northwest of Fort Wayne.
About ⅔ or two thirds of the way, you can stop at Kimmell, IN. This is almost an hour northwest of Fort Wayne, or about 18 minutes east of Syracuse, IN.
If you drive straight through without stopping at all, the total distance is 46 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 59 minutes.