About ¼ or a fourth of the way, you can stop at South Punta Gorda Heights, FL. This is about 17 minutes northwest of Fort Myers.
About ⅓ or a third of the way, you can stop at Punta Gorda, FL. This is about half an hour northwest of Fort Myers.
About ¾ or three fourths of the way, you can stop at Laurel, FL. This is about 1 hour northwest of Fort Myers, or about 19 minutes south of Sarasota.
If you drive straight through without stopping at all, the total distance is 77 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 1 hour, 21 minutes.