If you're looking for a meeting place or a good stop around ½ or halfway between Enterprise, Guyana and Lelydorp, you can try Wageningen, Suriname, which is about 3½ hours southeast of Enterprise, Guyana, or about 3½ hours west of Lelydorp.
About ¼ or a fourth of the way, you can stop at Corriverton, Guyana. This is about 2 hours southeast of Enterprise, Guyana.
About ⅓ or a third of the way, you can stop at Nieuw Nickerie, Suriname. This is a little over 2 hours southeast of Enterprise, Guyana.
About ⅔ or two thirds of the way, you can stop at Totness, Suriname. This is about 4½ hours southeast of Enterprise, Guyana, or almost 3 hours west of Lelydorp.
If you drive straight through without stopping at all, the total distance is 434 km. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 7 hours, 3 minutes.