If you're looking for a meeting place or a good stop around ½ or halfway between Edina and Omaha, you can try Ames, IA, which is about 3 hours south of Edina, or about 2½ hours northeast of Omaha.
About ¼ or a fourth of the way, you can stop at Albert Lea, MN. This is a little over 1 hour south of Edina.
About ⅓ or a third of the way, you can stop at Mason City, IA. This is almost 2 hours south of Edina.
About ⅔ or two thirds of the way, you can stop at West Des Moines, IA. This is almost 4 hours south of Edina, or almost 2 hours east of Omaha.
About ¾ or three fourths of the way, you can stop at Redfield, IA. This is about 4 hours south of Edina, or about 1½ hours east of Omaha.
If you drive straight through without stopping at all, the total distance is 374 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 5 hours, 28 minutes.