About ¼ or a fourth of the way, you can stop at Good Hope, LA. This is about 6 minutes northwest of Destrehan.
About ⅓ or a third of the way, you can stop at Prospect, LA. This is about 10 minutes northwest of Destrehan.
If you drive straight through without stopping at all, the total distance is 18 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 28 minutes.