If you're looking for a meeting place or a good stop around ½ or halfway between Columbus and Macatawa, you can try Auburn, IN, which is almost 3 hours northwest of Columbus, or almost 3 hours southeast of Macatawa.
About ¼ or a fourth of the way, you can stop at Lima, OH. This is a little over 1 hour northwest of Columbus.
About ⅓ or a third of the way, you can stop at Van Wert, OH. This is about 2 hours northwest of Columbus.
About ⅔ or two thirds of the way, you can stop at Girard, MI. This is almost 4 hours northwest of Columbus, or almost 2 hours southeast of Macatawa.
About ¾ or three fourths of the way, you can stop at Kalamazoo, MI. This is a little over 4 hours northwest of Columbus, or a little over 1 hour southeast of Macatawa.
If you drive straight through without stopping at all, the total distance is 337 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 5 hours, 29 minutes.