If you're looking for a meeting place or a good stop around ½ or halfway between Charlotte and Moncks Corner, you can try Columbia, SC, which is about 1½ hours south of Charlotte, or about 1½ hours northwest of Moncks Corner.
Other possible places to stop near the midpoint include Cayce, and Starmount.
About ¼ or a fourth of the way, you can stop at Tip Top, SC. This is about half an hour south of Charlotte.
About ⅓ or a third of the way, you can stop at Flint Hill, SC. This is almost an hour south of Charlotte.
About ⅔ or two thirds of the way, you can stop at Orangeburg, SC. This is about 2 hours south of Charlotte, or almost an hour northwest of Moncks Corner.
About ¾ or three fourths of the way, you can stop at Oaks Crossroads, SC. This is a little over 2 hours south of Charlotte, or almost an hour northwest of Moncks Corner.
If you drive straight through without stopping at all, the total distance is 196 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 3 hours.