If you're looking for a meeting place or a good stop around ½ or halfway between Canal Winchester and Huntersville, you can try Beckley, WV, which is about 3 hours southeast of Canal Winchester, or about 3½ hours north of Huntersville.
Other possible places to stop near the midpoint include Chelyan, and Kanawha Falls.
About ¼ or a fourth of the way, you can stop at Cheshire, OH. This is about 1½ hours southeast of Canal Winchester.
About ⅓ or a third of the way, you can stop at Charleston, WV. This is about 2 hours southeast of Canal Winchester.
About ⅔ or two thirds of the way, you can stop at Bluefield, VA. This is a little over 4 hours southeast of Canal Winchester, or about 2 hours north of Huntersville.
About ¾ or three fourths of the way, you can stop at Cliffview, VA. This is almost 5 hours southeast of Canal Winchester, or about 1½ hours north of Huntersville.
If you drive straight through without stopping at all, the total distance is 400 miles. The distances shown above don't include local roads to get into each town, so if you're planning a long road trip, make sure you factor in traffic and road conditions, rest stop breaks, and interesting detours along the way. If you're in a rush, you can do the trip with zero stops, and your total travel time would be around 6 hours, 20 minutes.
